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Test Code A1ALC Alpha-1-Antitrypsin Proteotype S/Z by LC-MS/MS, Serum

Useful For

Determining the specific proteotype for prognosis and genetic counseling for patients with alpha-1-antitrypsin deficiency

Profile Information

Test ID Reporting Name Available Separately Always Performed
A1ASZ A1AT Proteotype S/Z, LC-MS/MS No Yes
AATP Alpha-1-Antitrypsin, S Yes, (order AAT) Yes

Reflex Tests

Test ID Reporting Name Available Separately Always Performed
A1APR Alpha-1-Antitrypsin Phenotype, S Yes, (order A1APP) No

Testing Algorithm

If the mass spectrometry proteotype and quantitative serum level are discordant, then phenotyping will be added and performed at an additional charge.


See Alpha-1-Antitrypsin-A Comprehensive Testing Algorithm in Special Instructions.

Reporting Name

A1AT Proteotype S/Z, LC-MS/MS, S

Specimen Type


Specimen Required


Preferred: Red top

Acceptable: Serum gel

Specimen Volume: 1.25 mL

Specimen Minimum Volume

0.5 mL

Specimen Stability Information

Specimen Type Temperature Time Special Container
Serum Refrigerated (preferred) 28 days
  Ambient  28 days
  Frozen  28 days

Reject Due To

Gross hemolysis OK
Gross lipemia Reject
Gross icterus OK

Reference Values


100-190 mg/dL



Negative for S and Z phenotype (Non S Non Z)

Day(s) and Time(s) Performed

Monday, Thursday; 10 a.m.

Performing Laboratory

Mayo Clinic Laboratories in Rochester

CPT Code Information


82542-A1AT proteotype S/Z, LC-MS/MS

82104-Alpha-1-antitrypsin phenotype (if appropriate)

LOINC Code Information

Test ID Test Order Name Order LOINC Value
A1ALC A1AT Proteotype S/Z, LC-MS/MS, S In Process


Result ID Test Result Name Result LOINC Value
AATP Alpha-1-Antitrypsin, S 6771-0
34855 A1AT Proteotype S/Z, LC-MS/MS 49244-7

Method Name

A1ASZ: Liquid Chromatography-Tandem Mass Spectrometry (LC-MS/MS)

AATP: Nephelometry

A1APR: Isoelectric Focusing

Test Classification

This test was developed and its performance characteristics determined by Mayo Clinic in a manner consistent with CLIA requirements. This test has not been cleared or approved by the U.S. Food and Drug Administration.


If not ordering electronically, complete, print, and send a Gastroenterology and Hepatology Client Test Request (T728) with the specimen.